This will be the last world war mankind will have to fight. God will then cause the Euphrates river to dry up so that the armies of the world can gather together (along with the beast and false prophet) to fight Jesus coming directly from heaven (Revelation 16:12, 14). Just before Jesus returns to earth a second time, the kingdoms of the North and the South will begin making their preparations for the battle of Armageddon.

Sometime during the Great Tribulation, when the Beast and False Prophet rule the world, four demonic spirits that have been 'bound' or held at the waterway will be freed in order to unleash a wave of death upon all mankind (Revelation 9:13 - 15).

This area around the river will play a pivotal role in end time Bible prophecy. God promised to give him the land from the Nile River to the Euphrates, which was populated at the time by peoples such as the Kenites, Hittites, Amorites, Canaanites and others (Genesis 15). This covenant, which promised an inheritance in the land of Canaan, was made after Abraham had left his home in Ur of the Chaldees. In the same day the LORD made a covenant with Abram, saying, Unto thy seed have I have given this land, from the river of Egypt unto the great river. The Nile River is (likely reference) mentioned in Genesis 15:18. The river is also mentioned in regard to the covenant God made with Abram (Abraham). The River Euphrates is also known later in the Bible as the Mighty River. Now a river went out of Eden to water the garden, and from there it parted and became four river heads. The river's first mention is in the Bible book of Genesis: 'The Lord God planted a garden eastward in Eden, and there He put the man whom He had formed.

In modern times, the use of dams on the river generates power for the entire area. Mesopotamia eventually became the heartland of the Babylonian and Assyrian world empires. This area, where the invention of writing and the wheel occurred, is the cradle of civilization. The region around the Euphrates river is known as Mesopotamia.

River bible